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Production began in September 2011 at Studio Babelsberg in Potsdam-Babelsberg, Germany.
It premiered on 8 September 2012 at the 37th Toronto International Film Festival In the Chatham Islands, 1849, American lawyer Adam Ewing witnesses the whipping of a Moriori slave, Autua.
In Seoul, 2144, Sonmi-451 is a "fabricant," a human cloned for slave labor, living as a server at a fast food restaurant in a dystopian Neo Seoul, Korea.
She is exposed to ideas of rebellion by another fabricant and friend, Yoona-939.
In London, 2012, Dermot Hoggins, author of a gangster memoir, murders a critic after a harsh review, generating huge sales.
Hoggins's brothers threaten the book's publisher, the aging Timothy Cavendish, for Hoggins's share of the profits.
Denholme reveals to Timothy that he sent him there as revenge for Timothy's affair with Denholme's wife.Ayrs demands credit for "The Cloud Atlas Sextet" and threatens to expose Frobisher's homosexuality if he refuses.Frobisher shoots Ayrs and goes into hiding, using the name Ewing.The film was produced by Grant Hill, Stefan Arndt, the Wachowskis, and Tykwer.During four years of development, the project met difficulties securing financial support; it was eventually produced with a 2 million budget provided by independent sources, making it one of the most expensive independent films of all time.
Zachry, his brother-in-law Adam, and his nephew are attacked by the cannibalistic Kona tribe.